Vitamin D repletion ameliorates adipose tissue browning and muscle wasting in infantile nephropathic cystinosis‐associated cachexia

• Main Authors: Wai W. Cheung (Author), Sheng Hao (Author), Zhen Wang (Author), Wei Ding (Author), Ronghao Zheng (Author), Alex Gonzalez (Author), Jian‐Ying Zhan (Author), Ping Zhou (Author), Shiping Li (Author), Mary C. Esparza (Author), Hal M. Hoffman (Author), Richard L. Lieber (Author), Robert H. Mak (Author)
• Format: Book
• Published: Wiley, 2020-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Ctns−/− mice, a mouse model of infantile nephropathic cystinosis, exhibit hypermetabolism with adipose tissue browning and profound muscle wasting. Ctns−/− mice are 25(OH)D3 and 1,25(OH)2D3 insufficient. We investigated whether vitamin D repletion could ameliorate adipose tissue...