Regulation of CD163 Receptor in Patients with Abdominal Aortic Aneurysm and Associations with Antioxidant Enzymes HO-1 and NQO1

• Main Authors: Bianca Hamann (Author), Anna Klimova (Author), Felicia Klotz (Author), Frieda Frank (Author), Christian Jänichen (Author), Marvin Kapalla (Author), Pamela Sabarstinski (Author), Steffen Wolk (Author), Henning Morawietz (Author), David M. Poitz (Author), Anja Hofmann (Author), Christian Reeps (Author)
• Format: Book
• Published: MDPI AG, 2023-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Red blood cells are found within the abdominal aortic aneurysm (AAA), in the intraluminal thrombus (ILT), and in neovessels. Hemolysis promotes aortic degeneration, e.g., by heme-induced reactive oxygen species formation. To reduce its toxicity, hemoglobin is endocytosed by the CD163 receptor and he...