Anti-tubercular activity and molecular docking studies of indolizine derivatives targeting mycobacterial InhA enzyme

A series of 1,2,3-trisubstituted indolizines (2a-2f, 3a-3d, and 4a-4c) were screened for in vitro whole-cell anti-tubercular activity against the susceptible H37Rv and multidrug-resistant (MDR) Mycobacterium tuberculosis (MTB) strains. Compounds 2b-2d, 3a-3d, and 4a-4c were active against the H37Rv-...

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Main Authors: Katharigatta N. Venugopala (Author), Sandeep Chandrashekharappa (Author), Pran Kishore Deb (Author), Christophe Tratrat (Author), Melendhran Pillay (Author), Deepak Chopra (Author), Nizar A. Al-Shar'i (Author), Wafa Hourani (Author), Lina A. Dahabiyeh (Author), Pobitra Borah (Author), Rahul D. Nagdeve (Author), Susanta K. Nayak (Author), Basavaraj Padmashali (Author), Mohamed A. Morsy (Author), Bandar E. Aldhubiab (Author), Mahesh Attimarad (Author), Anroop B. Nair (Author), Nagaraja Sreeharsha (Author), Michelyne Haroun (Author), Sheena Shashikanth (Author), Viresh Mohanlall (Author), Raghuprasad Mailavaram (Author)
Formato: Livro
Publicado em: Taylor & Francis Group, 2021-01-01T00:00:00Z.
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