Comparison of Electrocardiographic Biomarkers for Differentiating Drug‐Induced Single vs. Multiple Cardiac Ion Channel Block

• Main Authors: Marina Brockway (Author), Jay W. Mason (Author), Brian P. Brockway (Author)
• פורמט: ספר
• יצא לאור: Wiley, 2019-05-01T00:00:00Z.
• נושאים: article
• גישה מקוונת: Connect to this object online.

Since introduction of the International Conference on Harmonization proarrhythmia guidelines in 2005, no new marketed drugs have been associated with unacceptable risk of Torsade de Pointes. Although cardiac safety improved, these guidelines had the unintended consequence of eliminating potentially...