Structure-based design of ligands of the m6A-RNA reader YTHDC1

• Príomhchruthaitheoirí: Yaozong Li (Údar), Rajiv Kumar Bedi (Údar), Francesco Nai (Údar), Valentin von Roten (Údar), Aymeric Dolbois (Údar), František Zálešák (Údar), Raed Nachawati (Údar), Danzhi Huang (Údar), Amedeo Caflisch (Údar)
• Formáid: LEABHAR
• Foilsithe / Cruthaithe: Elsevier, 2022-08-01T00:00:00Z.
• Ábhair: article
• Rochtain ar líne: Connect to this object online.

We report new chemical entities for disrupting the interactions between N6-methyladenosine (m6A) mRNA and its reader YT521-B homology-domain-containing protein 1 (YTHDC1). High-throughput docking was used to screen commercially available databases of small molecules, and molecular dynamics simulatio...