Investigating brain uptake of a non-targeting monoclonal antibody after intravenous and intracerebroventricular administration

• Main Authors: Arthur J. Van De Vyver (Author), Antje-Christine Walz (Author), Mariette S. Heins (Author), Afsaneh Abdolzade-Bavil (Author), Thomas E. Kraft (Author), Inja Waldhauer (Author), Michael B. Otteneder (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Monoclonal antibodies play an important role in the treatment of various diseases. However, the development of these drugs against neurological disorders where the drug target is located in the brain is challenging and requires a good understanding of the local drug concentration in the brain. In th...