Investigating brain uptake of a non-targeting monoclonal antibody after intravenous and intracerebroventricular administration

• मुख्य लेखकों: Arthur J. Van De Vyver (लेखक), Antje-Christine Walz (लेखक), Mariette S. Heins (लेखक), Afsaneh Abdolzade-Bavil (लेखक), Thomas E. Kraft (लेखक), Inja Waldhauer (लेखक), Michael B. Otteneder (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: Frontiers Media S.A., 2022-08-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

Monoclonal antibodies play an important role in the treatment of various diseases. However, the development of these drugs against neurological disorders where the drug target is located in the brain is challenging and requires a good understanding of the local drug concentration in the brain. In th...