Investigation of 1,4-Substituted 1,2,3-Triazole Derivatives as Antiarrhythmics: Synthesis, Structure, and Properties

• Main Authors: Elena O. Shestakova (Author), Sergey G. Il'yasov (Author), Irina A. Shchurova (Author), Vera S. Glukhacheva (Author), Dmitri S. Il'yasov (Author), Egor E. Zhukov (Author), Arkady O. Bryzgalov (Author), Tatiana G. Tolstikova (Author), Yuri V. Gatilov (Author)
• Format: Book
• Published: MDPI AG, 2022-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Here, we investigated the reaction of 1,3-dipolar cycloaddition of 1,3-diazido-2-nitro-2- azapropane (DANP) to propargyl alcohol over a copper-based catalyst and identified the optimum reaction conditions that enable the synthesis of 2-nitro-1,3-bis(4,4'-dihydroxymethyl)-1,2,3-triazolyl-2-azapr...