Systemic RNAi-mediated Gene Silencing in Nonhuman Primate and Rodent Myeloid Cells

• Main Authors: Tatiana I Novobrantseva (Author), Anna Borodovsky (Author), Jamie Wong (Author), Boris Klebanov (Author), Mohammad Zafari (Author), Kristina Yucius (Author), William Querbes (Author), Pei Ge (Author), Vera M Ruda (Author), Stuart Milstein (Author), Lauren Speciner (Author), Rick Duncan (Author), Scott Barros (Author), Genc Basha (Author), Pieter Cullis (Author), Akin Akinc (Author), Jessica S Donahoe (Author), K Narayanannair Jayaprakash (Author), Muthusamy Jayaraman (Author), Roman L Bogorad (Author), Kevin Love (Author), Katie Whitehead (Author), Chris Levins (Author), Muthiah Manoharan (Author), Filip K Swirski (Author), Ralph Weissleder (Author), Robert Langer (Author), Daniel G Anderson (Author), Antonin de Fougerolles (Author), Matthias Nahrendorf (Author), Victor Koteliansky (Author)
• Format: Book
• Published: Elsevier, 2012-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Leukocytes are central regulators of inflammation and the target cells of therapies for key diseases, including autoimmune, cardiovascular, and malignant disorders. Efficient in vivo delivery of small interfering RNA (siRNA) to immune cells could thus enable novel treatment strategies with broad app...