NADPH Oxidase Mediates Oxidative Stress and Ventricular Remodeling through SIRT3/FOXO3a Pathway in Diabetic Mice

• Main Authors: Jiuchun Qiu (Author), Daiqi Liu (Author), Pengsha Li (Author), Lingling Zhou (Author), Lu Zhou (Author), Xing Liu (Author), Yue Zhang (Author), Meng Yuan (Author), Gary Tse (Author), Guangping Li (Author), Tong Liu (Author)
• Format: Book
• Published: MDPI AG, 2022-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Oxidative stress and mitochondrial dysfunction are important mechanisms of ventricular remodeling, predisposed to the development of diabetic cardiomyopathy (DCM) in type 2 diabetes mellitus. In this study, we have successfully established a model of type 2 diabetes using a high-fat diet (HFD) in co...