Involvement of GPR4 in increased growth hormone and prolactin expressions by extracellular acidification in MtT/S cells

• Main Authors: Shiori MUSHA (Author), Saishu YOSHIDA (Author), Syo MURAKAMI (Author), Ryotaro KOJIMA (Author), Masahito DEAI (Author), Naoshi SASO (Author), Chihiro MOGI (Author), Koichi SATO (Author), Fumikazu OKAJIMA (Author), Hideaki TOMURA (Author)
• Format: Book
• Published: The Society for Reproduction and Development, 2020-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Hormone-secreting pituitary adenomas show unregulated hormonal hypersecretion and cause hyperpituitarism. However, the mechanism of the unregulated hormone production and secretion has not yet been fully elucidated. Solid tumors show reduced extracellular pH, partly due to lactate secretion from ana...