Controlled-Deactivation CB1 Receptor Ligands as a Novel Strategy to Lower Intraocular Pressure

• Main Authors: Sally Miller (Author), Shashank Kulkarni (Author), Alex Ciesielski (Author), Spyros P. Nikas (Author), Ken Mackie (Author), Alexandros Makriyannis (Author), Alex Straiker (Author)
• Format: Book
• Published: MDPI AG, 2018-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Nearly half a century has passed since the demonstration that cannabis and its chief psychoactive component Δ9-THC lowers intraocular pressure (IOP). Elevated IOP remains the chief hallmark and therapeutic target for glaucoma, a condition that places millions at risk of blindness. It is li...