Treatment of chronic osteomyelitis with gradient release of DGEA and vancomycin hydrogel-microsphere system and its mechanism

• Main Authors: Yuhao Zheng (Author), Yue Wang (Author), Fan Sheng (Author), Shu Wang (Author), Ying Zhou (Author), Xiaoxu Li (Author), Ning Li (Author), Wenling Song (Author), Zhiming Song (Author)
• Format: Book
• Published: Frontiers Media S.A., 2024-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

In recent years, the treatment of chronic osteomyelitis mediated by biodegradable polymer platforms has received increasing attention. This paper reports an advanced drug delivery system, vancomycin (VA) and DGEA loaded microspheres embedded in injectable thermosensitive polypeptide hydrogels (i.e.,...