Feed-Forward Inhibition of CD73 and Upregulation of Adenosine Deaminase Contribute to the Loss of Adenosine Neuromodulation in Postinflammatory Ileitis

• Main Authors: Cátia Vieira (Author), Maria Teresa Magalhães-Cardoso (Author), Fátima Ferreirinha (Author), Isabel Silva (Author), Ana Sofia Dias (Author), Julie Pelletier (Author), Jean Sévigny (Author), Paulo Correia- (Author)
• Format: Book
• Published: Hindawi Limited, 2014-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Purinergic signalling is remarkably plastic during gastrointestinal inflammation. Thus, selective drugs targeting the "purinome" may be helpful for inflammatory gastrointestinal diseases. The myenteric neuromuscular transmission of healthy individuals is fine-tuned and controlled by adenos...