Bioequivalence and food effect of a fixed‐dose combination of macitentan and tadalafil: Adaptive design in the COVID‐19 pandemic

Bioequivalence and food effect of a fixed‐dose combination of macitentan and tadalafil: Adaptive design in the COVID‐19 pandemic

Abstract The COVID‐19 pandemic has forced clinical studies to accommodate imposed limitations. In this study, the bioequivalence part could not be conducted as planned. Thus, the aim was to demonstrate bioequivalence, using an adaptive study design, of tadalafil in fixed‐dose combination (FDC) table...

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Main Authors: Dénes Csonka (Author), Vladislav Fishman (Author), Jaya Natarajan (Author), Hans Stieltjes (Author), Danielle Armas (Author), Victor Dishy (Author), Juan Jose Perez Ruixo (Author)
Format: Book
Published: Wiley, 2021-10-01T00:00:00Z.
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