Bioequivalence and food effect of a fixed‐dose combination of macitentan and tadalafil: Adaptive design in the COVID‐19 pandemic

• المؤلفون الرئيسيون: Dénes Csonka (مؤلف), Vladislav Fishman (مؤلف), Jaya Natarajan (مؤلف), Hans Stieltjes (مؤلف), Danielle Armas (مؤلف), Victor Dishy (مؤلف), Juan Jose Perez Ruixo (مؤلف)
• التنسيق: كتاب
• منشور في: Wiley, 2021-10-01T00:00:00Z.
• الموضوعات: article
• الوصول للمادة أونلاين: Connect to this object online.

Abstract The COVID‐19 pandemic has forced clinical studies to accommodate imposed limitations. In this study, the bioequivalence part could not be conducted as planned. Thus, the aim was to demonstrate bioequivalence, using an adaptive study design, of tadalafil in fixed‐dose combination (FDC) table...