Nicorandil alleviates cardiac microvascular ferroptosis in diabetic cardiomyopathy: Role of the mitochondria-localized AMPK-Parkin-ACSL4 signaling pathway

• Main Authors: Zhangwei Chen (Author), Su Li (Author), Muyin Liu (Author), Ming Yin (Author), Jinxiang Chen (Author), Youran Li (Author), Qiyu Li (Author), You Zhou (Author), Yan Xia (Author), Ao Chen (Author), Danbo Lu (Author), Chenguang Li (Author), Yuqiong Chen (Author), Juying Qian (Author), Junbo Ge (Author)
• Format: Book
• Published: Elsevier, 2024-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Mitochondria-associated ferroptosis exacerbates cardiac microvascular dysfunction in diabetic cardiomyopathy (DCM). Nicorandil, an ATP-sensitive K+ channel opener, protects against endothelial dysfunction, mitochondrial dysfunction, and DCM; however, its effects on ferroptosis and mitophagy remain u...