Fibroblast activation protein (FAP) as a novel metabolic target

• Main Authors: Miguel Angel Sánchez-Garrido (Author), Kirk M. Habegger (Author), Christoffer Clemmensen (Author), Cassie Holleman (Author), Timo D. Müller (Author), Diego Perez-Tilve (Author), Pengyun Li (Author), Archita S. Agrawal (Author), Brian Finan (Author), Daniel J. Drucker (Author), Matthias H. Tschöp (Author), Richard D. DiMarchi (Author), Alexei Kharitonenkov (Author)
• Format: Book
• Published: Elsevier, 2016-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Fibroblast activation protein (FAP) is a serine protease belonging to a S9B prolyl oligopeptidase subfamily. This enzyme has been implicated in cancer development and recently reported to regulate degradation of FGF21, a potent metabolic hormone. Using a known FAP inhibitor, talabostat (T...