A role of TRPA1 in mechanical hyperalgesia is revealed by pharmacological inhibition

• Main Authors: Huynh Truc (Author), Hwang Sun (Author), Bandell Michael (Author), Peier Andrea M (Author), Petrus Matt (Author), Olney Nicholas (Author), Jegla Tim (Author), Patapoutian Ardem (Author)
• Format: Book
• Published: SAGE Publishing, 2007-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

<p>Abstract</p> <p>Mechanical hyperalgesia is a clinically-relevant form of pain sensitization that develops through largely unknown mechanisms. TRPA1, a Transient Receptor Potential ion channel, is a sensor of pungent chemicals that may play a role in acute noxious mechanosensatio...