Critical appraisal of the piRNA-PIWI axis in cancer and cancer stem cells

• Main Authors: Elena Garcia-Borja (Author), Frantisek Siegl (Author), Rosana Mateu (Author), Ondrej Slaby (Author), Aleksi Sedo (Author), Petr Busek (Author), Jiri Sana (Author)
• Format: Book
• Published: BMC, 2024-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Small noncoding RNAs play an important role in various disease states, including cancer. PIWI proteins, a subfamily of Argonaute proteins, and PIWI-interacting RNAs (piRNAs) were originally described as germline-specific molecules that inhibit the deleterious activity of transposable elemen...