Nonocarbolines A-E, <i>β</i>-Carboline Antibiotics Produced by the Rare Actinobacterium <i>Nonomuraea</i> sp. from Indonesia
During the course of our ongoing screening for novel biologically active secondary metabolites, the rare Actinobacterium, <i>Nonomuraea</i> sp. 1808210CR was found to produce five unprecedented <i>β</i>-carboline derivatives, nonocarbolines A−E (<b>1−5</b>). Their...
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| Main Authors: | , , , , , , |
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| Format: | Book |
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MDPI AG,
2020-03-01T00:00:00Z.
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| Online Access: | Connect to this object online. |
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| Summary: | During the course of our ongoing screening for novel biologically active secondary metabolites, the rare Actinobacterium, <i>Nonomuraea</i> sp. 1808210CR was found to produce five unprecedented <i>β</i>-carboline derivatives, nonocarbolines A−E (<b>1−5</b>). Their structures were elucidated from high-resolution mass spectrometry, 1D and 2D nuclear magnetic resonance spectroscopy, and the absolute configuration of <b>4</b> was determined by using the modified Mosher method. Nonocarboline B (<b>2</b>) displayed moderate antifungal activity against <i>Mucor hiemalis</i>, while nonocarboline D (<b>4</b>) exhibited significant cytotoxic activity against the human lung carcinoma cell line A-549 with the IC<sub>50</sub> value of 1.7 µM. |
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| Item Description: | 2079-6382 10.3390/antibiotics9030126 |