Multi-omics after O-GlcNAc alteration identified cellular processes promoting aneuploidy after loss of O-GlcNAc transferase

• Main Authors: Samuel S. Boyd (Author), Dakota R. Robarts (Author), Khue Nguyen (Author), Maite Villar (Author), Ibtihal M. Alghusen (Author), Manasi Kotulkar (Author), Aspin Denson (Author), Halyna Fedosyuk (Author), Stephen A. Whelan (Author), Norman C.Y. Lee (Author), John Hanover (Author), Wagner B. Dias (Author), Ee Phie Tan (Author), Steven R. McGreal (Author), Antonio Artigues (Author), Russell H. Swerdlow (Author), Jeffrey A. Thompson (Author), Udayan Apte (Author), Chad Slawson (Author)
• Format: Book
• Published: Elsevier, 2024-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Pharmacologic or genetic manipulation of O-GlcNAcylation, an intracellular, single sugar post-translational modification, are difficult to interpret due to the pleotropic nature of O-GlcNAc and the vast signaling pathways it regulates. Method: To address the pleotropic nature of O-GlcNAc,...