Natural history study and statistical modeling of disease progression in a preclinical model of myotubular myopathy

• Main Authors: Suzie Buono (Author), Arnaud Monseur (Author), Alexia Menuet (Author), Anne Robé (Author), Catherine Koch (Author), Jocelyn Laporte (Author), Leen Thielemans (Author), Marion Depla (Author), Belinda S. Cowling (Author)
• Format: Book
• Published: The Company of Biologists, 2022-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Generating reliable preclinical data in animal models of disease is essential in therapy development. Here, we performed statistical analysis and joint longitudinal-survival modeling of the progressive phenotype observed in Mtm1−/y mice, a reliable model for myotubular myopathy. Analysis of historic...