Natural history study and statistical modeling of disease progression in a preclinical model of myotubular myopathy

• Prif Awduron: Suzie Buono (Awdur), Arnaud Monseur (Awdur), Alexia Menuet (Awdur), Anne Robé (Awdur), Catherine Koch (Awdur), Jocelyn Laporte (Awdur), Leen Thielemans (Awdur), Marion Depla (Awdur), Belinda S. Cowling (Awdur)
• Fformat: Llyfr
• Cyhoeddwyd: The Company of Biologists, 2022-07-01T00:00:00Z.
• Pynciau: article
• Mynediad Ar-lein: Connect to this object online.

Generating reliable preclinical data in animal models of disease is essential in therapy development. Here, we performed statistical analysis and joint longitudinal-survival modeling of the progressive phenotype observed in Mtm1−/y mice, a reliable model for myotubular myopathy. Analysis of historic...