Vascular stiffening in aging females with a hypertension‐induced HIF2A gain‐of‐function mutation

• Glavni autori: Eugenia Volkova (Autor), Linda Procell (Autor), Lingyang Kong (Autor), Lakshmi Santhanam (Autor), Sharon Gerecht (Autor)
• Format: Knjiga
• Izdano: Wiley, 2023-03-01T00:00:00Z.
• Teme: article
• Online pristup: Connect to this object online.

Abstract Pulmonary arterial hypertension (PAH) is more prevalent in females than males; the causes of this sex difference have not been adequately explored. Gain‐of‐function (GOF) mutations in hypoxia‐inducible factor 2α (HIF2A) lead to PAH and thrombotic consequences in patients and mice. Additiona...