Functional expression of parasite drug targets and their human orthologs in yeast.

• Main Authors: Elizabeth Bilsland (Author), Pınar Pir (Author), Alex Gutteridge (Author), Alexander Johns (Author), Ross D King (Author), Stephen G Oliver (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2011-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The exacting nutritional requirements and complicated life cycles of parasites mean that they are not always amenable to high-throughput drug screening using automated procedures. Therefore, we have engineered the yeast Saccharomyces cerevisiae to act as a surrogate for expressing anti-parasitic tar...