Functional expression of parasite drug targets and their human orthologs in yeast.

• Asıl Yazarlar: Elizabeth Bilsland (Yazar), Pınar Pir (Yazar), Alex Gutteridge (Yazar), Alexander Johns (Yazar), Ross D King (Yazar), Stephen G Oliver (Yazar)
• Materyal Türü: Kitap
• Baskı/Yayın Bilgisi: Public Library of Science (PLoS), 2011-10-01T00:00:00Z.
• Konular: article
• Online Erişim: Connect to this object online.

The exacting nutritional requirements and complicated life cycles of parasites mean that they are not always amenable to high-throughput drug screening using automated procedures. Therefore, we have engineered the yeast Saccharomyces cerevisiae to act as a surrogate for expressing anti-parasitic tar...