Impairment of adrenergically-regulated thermogenesis in brown fat of obesity-resistant mice is compensated by non-shivering thermogenesis in skeletal muscle

• Main Authors: Petra Janovska (Author), Petr Zouhar (Author), Kristina Bardova (Author), Jakub Otahal (Author), Marek Vrbacky (Author), Tomas Mracek (Author), Katerina Adamcova (Author), Lucie Lenkova (Author), Jiri Funda (Author), Tomas Cajka (Author), Zdenek Drahota (Author), Sara Stanic (Author), Arild C. Rustan (Author), Olga Horakova (Author), Josef Houstek (Author), Martin Rossmeisl (Author), Jan Kopecky (Author)
• Format: Book
• Published: Elsevier, 2023-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Non-shivering thermogenesis (NST) mediated by uncoupling protein 1 (UCP1) in brown adipose tissue (BAT) can be activated via the adrenergic system in response to cold or diet, contributing to both thermal and energy homeostasis. Other mechanisms, including metabolism of skeletal muscle, m...