Development of Folate-Functionalized PEGylated Zein Nanoparticles for Ligand-Directed Delivery of Paclitaxel

• Main Authors: Zar Chi Soe (Author), Wenquan Ou (Author), Milan Gautam (Author), Kishwor Poudel (Author), Bo Kyun Kim (Author), Le Minh Pham (Author), Cao Dai Phung (Author), Jee-Heon Jeong (Author), Sung Giu Jin (Author), Han-Gon Choi (Author), Sae Kwang Ku (Author), Chul Soon Yong (Author), Jong Oh Kim (Author)
• Format: Book
• Published: MDPI AG, 2019-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

In this study, we investigated the active targeted delivery of a hydrophobic drug, paclitaxel (PTX), via receptor-mediated endocytosis by folate receptors expressed on cancer cells using a protein-based nanoparticle system. PTX was loaded on zein nanoparticles and conjugated with folate (PTX/Zein-FA...