Human islets contain a subpopulation of glucagon-like peptide-1 secreting α cells that is increased in type 2 diabetes

• Main Authors: Scott A. Campbell (Author), Dominic P. Golec (Author), Matt Hubert (Author), Janyne Johnson (Author), Nicole Salamon (Author), Amy Barr (Author), Patrick E. MacDonald (Author), Koenraad Philippaert (Author), Peter E. Light (Author)
• Format: Book
• Published: Elsevier, 2020-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objectives: Our study shows that glucagon-like peptide-1 (GLP-1) is secreted within human islets and may play an unexpectedly important paracrine role in islet physiology and pathophysiology. It is known that α cells within rodent and human pancreatic islets are capable of secreting GLP-1, but littl...