Design and Synthesis of Novel Thiazolo[5,4-d]pyrimidine Derivatives with High Affinity for Both the Adenosine A₁ and A_2A Receptors, and Efficacy in Animal Models of Depression

• Main Authors: Flavia Varano (Author), Daniela Catarzi (Author), Erica Vigiani (Author), Diego Dal Ben (Author), Michela Buccioni (Author), Gabriella Marucci (Author), Lorenzo Di Cesare Mannelli (Author), Elena Lucarini (Author), Carla Ghelardini (Author), Rosaria Volpini (Author), Vittoria Colotta (Author)
• Format: Book
• Published: MDPI AG, 2021-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

New compounds with a 7-amino-2-arylmethyl-thiazolo[5,4-d]pyrimidine structure were synthesized and evaluated in vitro for their affinity and/or potency at the human (h) A₁, hA_2A, hA_2B, and hA₃ adenosine recep...