Z-ligustilide preferentially caused mitochondrial dysfunction in AML HL-60 cells by activating nuclear receptors NUR77 and NOR1

• Main Authors: Gen Liu (Author), Zhi-gang Chen (Author), Li-rong Yang (Author), Yu-xia Rong (Author), Qin Wang (Author), Li Li (Author), Qian-wei Lu (Author), Ming-dong Jiang (Author), Hong-yi Qi (Author)
• Format: Book
• Published: BMC, 2023-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Nuclear receptors NUR77 and NOR1 were identified as critical targets in acute myeloid leukemia (AML) therapy. Previously, we showed that Z-ligustilide (Z-LIG) selectively targeted AML by restoring NUR77 and NOR1. However, its downstream mechanisms are yet to be elucidated. Method...