Z-ligustilide preferentially caused mitochondrial dysfunction in AML HL-60 cells by activating nuclear receptors NUR77 and NOR1

• Hauptverfasser: Gen Liu (Verfasst von), Zhi-gang Chen (Verfasst von), Li-rong Yang (Verfasst von), Yu-xia Rong (Verfasst von), Qin Wang (Verfasst von), Li Li (Verfasst von), Qian-wei Lu (Verfasst von), Ming-dong Jiang (Verfasst von), Hong-yi Qi (Verfasst von)
• Format: Buch
• Veröffentlicht: BMC, 2023-09-01T00:00:00Z.
• Schlagworte: article
• Online-Zugang: Connect to this object online.

Abstract Background Nuclear receptors NUR77 and NOR1 were identified as critical targets in acute myeloid leukemia (AML) therapy. Previously, we showed that Z-ligustilide (Z-LIG) selectively targeted AML by restoring NUR77 and NOR1. However, its downstream mechanisms are yet to be elucidated. Method...