The Antagonism of 5-HT6 Receptor Attenuates Current-Induced Spikes and Improves Long-Term Potentiation via the Regulation of M-Currents in a Pilocarpine-Induced Epilepsy Model

• Main Authors: Chaofeng Zhu (Author), Rong Lin (Author), Changyun Liu (Author), Mingzhu Huang (Author), Feng Lin (Author), Gan Zhang (Author), Yuying Zhang (Author), Junjie Miao (Author), Wanhui Lin (Author), Huapin Huang (Author)
• Format: Book
• Published: Frontiers Media S.A., 2020-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Recent studies have documented that reduced M-current promotes epileptogenesis and attenuates synaptic remodeling. Neurite growth is closely related to the level of 5-HT6 receptor (5-HT6R) in the central nervous system. However, little research is available regarding the relation between 5-HT6R and...