A technology platform for standardized cryoprotection and freezing of large-volume brain tissues for high-resolution histology

• Main Authors: Ramdayalan Kumarasami (Author), Richa Verma (Author), Karthika Pandurangan (Author), Jivitha Jyothi Ramesh (Author), Sathish Pandidurai (Author), Stephen Savoia (Author), Jaikishan Jayakumar (Author), Mihail Bota (Author), Partha Mitra (Author), Jayaraj Joseph (Author), Mohanasankar Sivaprakasam (Author)
• Format: Book
• Published: Frontiers Media S.A., 2023-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Understanding and mapping the human connectome is a long-standing endeavor of neuroscience, yet the significant challenges associated with the large size of the human brain during cryosectioning remain unsolved. While smaller brains, such as rodents and marmosets, have been the focus of previous con...