A multistate modeling and simulation framework to learn dose-response of oncology drugs: Application to bintrafusp alfa in non‐small cell lung cancer

• Asıl Yazarlar: Han Liu (Yazar), Ana‐Marija Milenković‐Grišić (Yazar), Sreenath M. Krishnan (Yazar), Siv Jönsson (Yazar), Lena E. Friberg (Yazar), Pascal Girard (Yazar), Karthik Venkatakrishnan (Yazar), Yulia Vugmeyster (Yazar), Akash Khandelwal (Yazar), Mats O. Karlsson (Yazar)
• Materyal Türü: Kitap
• Baskı/Yayın Bilgisi: Wiley, 2023-11-01T00:00:00Z.
• Konular: article
• Online Erişim: Connect to this object online.

Abstract The dose/exposure‐efficacy analyses are often conducted separately for oncology end points like best overall response, progression‐free survival (PFS) and overall survival (OS). Multistate models offer to bridge these dose‐end point relationships by describing transitions and transition tim...