Ion-Complex Microcrystal Formulation Provides Sustained Delivery of a Multimodal Kinase Inhibitor from the Subconjunctival Space for Protection of Retinal Ganglion Cells

• Main Authors: Henry T. Hsueh (Author), Yoo-Chun Kim (Author), Ian Pitha (Author), Matthew D. Shin (Author), Cynthia A. Berlinicke (Author), Renee Ti Chou (Author), Elizabeth Kimball (Author), Julie Schaub (Author), Sarah Quillen (Author), Kirby T. Leo (Author), Hyounkoo Han (Author), Amy Xiao (Author), Youngwook Kim (Author), Matthew Appell (Author), Usha Rai (Author), HyeYoung Kwon (Author), Patricia Kolodziejski (Author), Laolu Ogunnaike (Author), Nicole M. Anders (Author), Avelina Hemingway (Author), Joan L. Jefferys (Author), Abhijit A. Date (Author), Charles Eberhart (Author), Thomas V. Johnson (Author), Harry A. Quigley (Author), Donald J. Zack (Author), Justin Hanes (Author), Laura M. Ensign (Author)
• Format: Book
• Published: MDPI AG, 2021-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Glaucoma is the leading cause of irreversible blindness worldwide. Elevated intraocular pressure (IOP) is one of the major risk factors for glaucoma onset and progression, and available pharmaceutical interventions are exclusively targeted at IOP lowering. However, degeneration of retinal ganglion c...