Female sex hormones are necessary for the metabolic effects mediated by loss of Interleukin 18 signaling

• Main Authors: Birgitte Lindegaard (Author), Julie Abildgaard (Author), Sarah E. Heywood (Author), Bente K. Pedersen (Author), Mark A. Febbraio (Author)
• Format: Book
• Published: Elsevier, 2018-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Interleukin (IL)-18 plays a crucial role in maintaining metabolic homeostasis and levels of this cytokine are influenced by gender, age, and sex hormones. The role of gender on IL-18 signaling, however, is unclear. We hypothesized that the presence of female sex hormone could preserve the...