A thermosensitive mutation alters the effects of lacosamide on slow inactivation in neuronal voltage-gated sodium channels, NaV 1.2.Mena Abdelsayed1, Stanislav Sokolov1, Peter C. Ruben*1 - These authors contributed equally to this work* - Corresponding author

A thermosensitive mutation alters the effects of lacosamide on slow inactivation in neuronal voltage-gated sodium channels, NaV 1.2.Mena Abdelsayed1, Stanislav Sokolov1, Peter C. Ruben*1 - These authors contributed equally to this work* - Corresponding author

Epilepsy is a disorder characterized by seizures and convulsions. The basis of epilepsy is an increase in neuronal excitability that, in some cases, may be caused by functional defects in neuronal voltage gated sodium channels (NaVs). The C121W mutation of the β1 subunit, in particular, gives rise t...

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Main Authors: Mena eAbdelsayed (Author), Stanislav eSokolov (Author), Peter eRuben (Author)
Format: Book
Published: Frontiers Media S.A., 2013-09-01T00:00:00Z.
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