Entecavir as a P2X7R antagonist ameliorates platelet activation and thrombus formation

• Main Authors: Yue Ming (Author), Guang Xin (Author), Beihong Ji (Author), Chengji Ji (Author), Zeliang Wei (Author), Boli Zhang (Author), Junhua Zhang (Author), Kui Yu (Author), Xiaoyu Zhang (Author), Shiyi Li (Author), Youping Li (Author), Zhihua Xing (Author), Hai Niu (Author), Wen Huang (Author)
• Format: Book
• Published: Elsevier, 2020-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Platelet activation is the primary cause of thrombosis. The P2X7 receptor (P2X7R) is a therapeutic target of thrombosis. However, it is still unknown whether P2X7R activation affects platelet thrombus. Our molecular docking results showed that entecavir as a P2X7R antagonist interacted perfectly wit...