Peptide Adjuvant to Invigorate Cytolytic Activity of NK Cells in an Obese Mouse Cancer Model

• Main Authors: Seungmin Han (Author), Minjin Jung (Author), Angela S. Kim (Author), Daniel Y. Lee (Author), Byung-Hyun Cha (Author), Charles W. Putnam (Author), Kwang Suk Lim (Author), David A. Bull (Author), Young-Wook Won (Author)
• Format: Book
• Published: MDPI AG, 2021-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Cancer patients who are overweight compared to those with normal body weight have obesity-associated alterations of natural killer (NK) cells, characterized by poor cytotoxicity, slow proliferation, and inadequate anti-cancer activity. Concomitantly, prohibitin overexpressed by cancer cells elevates...