The Effect of VPA Treatment on Radiolabeled DOTATATE Uptake: Differences Observed In Vitro and In Vivo

• Main Authors: Maria J. Klomp (Author), Leo J. Hofland (Author), Lilian van den Brink (Author), Peter M. van Koetsveld (Author), Fadime Dogan (Author), Corrina M. A. de Ridder (Author), Debra C. Stuurman (Author), Marian C. Clahsen-van Groningen (Author), Marion de Jong (Author), Simone U. Dalm (Author)
• Format: Book
• Published: MDPI AG, 2022-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

<b>Background:</b> To improve peptide receptor radionuclide therapy (PRRT), we aimed to enhance the expression of somatostatin type-2 receptors (SSTR2) in vitro and in vivo, using valproic acid (VPA). <b>Methods:</b> Human NCI-H69 small-cell lung carcinoma cells were treated...