Precision sirolimus dosing in children: The potential for model-informed dosing and novel drug monitoring

• Main Authors: Guofang Shen (Author), Kao Tang Ying Moua (Author), Kathryn Perkins (Author), Deron Johnson (Author), Arthur Li (Author), Peter Curtin (Author), Wei Gao (Author), Jeannine S. McCune (Author)
• Format: Book
• Published: Frontiers Media S.A., 2023-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The mTOR inhibitor sirolimus is prescribed to treat children with varying diseases, ranging from vascular anomalies to sporadic lymphangioleiomyomatosis to transplantation (solid organ or hematopoietic cell). Precision dosing of sirolimus using therapeutic drug monitoring (TDM) of sirolimus concentr...