A New Experimental Polytrauma Model in Rats: Molecular Characterization of the Early Inflammatory Response

• Main Authors: Sebastian Weckbach (Author), Mario Perl (Author), Tim Heiland (Author), Sonja Braumüller (Author), Philip F. Stahel (Author), Michael A. Flierl (Author), Anita Ignatius (Author), Florian Gebhard (Author), Markus Huber-Lang (Author)
• Format: Book
• Published: Hindawi Limited, 2012-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background. The molecular mechanisms of the immune response after polytrauma are highly complex and far from fully understood. In this paper, we characterize a new standardized polytrauma model in rats based on the early molecular inflammatory and apoptotic response. Methods. Male Wistar rats (250 g...