Cluster Gauss‐Newton method analyses of PBPK model parameter combinations of coproporphyrin‐I based on OATP1B‐mediated rifampicin interaction studies

• 主要な著者: Takashi Yoshikado (著者), Yasunori Aoki (著者), Tatsuki Mochizuki (著者), A. David Rodrigues (著者), Koji Chiba (著者), Hiroyuki Kusuhara (著者), Yuichi Sugiyama (著者)
• フォーマット: 図書
• 出版事項: Wiley, 2022-10-01T00:00:00Z.
• 主題: article
• オンライン･アクセス: Connect to this object online.

Abstract Coproporphyrin I (CP‐I) is an endogenous biomarker supporting the prediction of drug-drug interactions (DDIs) involving hepatic organic anion transporting polypeptide 1B (OATP1B). We previously constructed a physiologically‐based pharmacokinetic (PBPK) model for CP‐I using clinical DDI data...