Deletion of Fibrinogen-like Protein 2 (FGL-2), a Novel CD4+ CD25+ Treg Effector Molecule, Leads to Improved Control of Echinococcus multilocularis Infection in Mice.

• Main Authors: Junhua Wang (Author), Dominique A Vuitton (Author), Norbert Müller (Author), Andrew Hemphill (Author), Markus Spiliotis (Author), Oleg Blagosklonov (Author), Denis Grandgirard (Author), Stephen L Leib (Author), Itay Shalev (Author), Gary Levy (Author), Xiaomei Lu (Author), Renyong Lin (Author), Hao Wen (Author), Bruno Gottstein (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2015-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

BACKGROUND:The growth potential of the tumor-like Echinococcus multilocularis metacestode (causing alveolar echinococcosis, AE) is directly linked to the nature/function of the periparasitic host immune-mediated processes. We previously showed that Fibrinogen-like-protein 2 (FGL2), a novel CD4+CD25+...