Forced enhancer-promoter rewiring to alter gene expression in animal models

• Main Authors: Scott A. Peslak (Author), Selami Demirci (Author), Vemika Chandra (Author), Byoung Ryu (Author), Saurabh K. Bhardwaj (Author), Jing Jiang (Author), Jeremy W. Rupon (Author), Robert E. Throm (Author), Naoya Uchida (Author), Alexis Leonard (Author), Khaled Essawi (Author), Aylin C. Bonifacino (Author), Allen E. Krouse (Author), Nathaniel S. Linde (Author), Robert E. Donahue (Author), Francesca Ferrara (Author), Matthew Wielgosz (Author), Osheiza Abdulmalik (Author), Nicole Hamagami (Author), Paula Germino-Watnick (Author), Anh Le (Author), Rebecca Chu (Author), Malikiya Hinds (Author), Mitchell J. Weiss (Author), Wei Tong (Author), John F. Tisdale (Author), Gerd A. Blobel (Author)
• Format: Book
• Published: Elsevier, 2023-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Transcriptional enhancers can be in physical proximity of their target genes via chromatin looping. The enhancer at the β-globin locus (locus control region [LCR]) contacts the fetal-type (HBG) and adult-type (HBB) β-globin genes during corresponding developmental stages. We have demonstrated previo...