Insulin-like growth factor receptor signaling regulates working memory, mitochondrial metabolism, and amyloid-β uptake in astrocytes

• Main Authors: Sreemathi Logan (Author), Gavin A. Pharaoh (Author), M. Caleb Marlin (Author), Dustin R. Masser (Author), Satoshi Matsuzaki (Author), Benjamin Wronowski (Author), Alexander Yeganeh (Author), Eileen E. Parks (Author), Pavithra Premkumar (Author), Julie A. Farley (Author), Daniel B. Owen (Author), Kenneth M. Humphries (Author), Michael Kinter (Author), Willard M. Freeman (Author), Luke I. Szweda (Author), Holly Van Remmen (Author), William E. Sonntag (Author)
• Format: Book
• Published: Elsevier, 2018-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: A decline in mitochondrial function and biogenesis as well as increased reactive oxygen species (ROS) are important determinants of aging. With advancing age, there is a concomitant reduction in circulating levels of insulin-like growth factor-1 (IGF-1) that is closely associated with neu...