Inconsistent protective efficacy and marked polymorphism limits the value of Schistosoma japonicum tetraspanin-2 as a vaccine target.

• मुख्य लेखकों: Wenbao Zhang (लेखक), Jun Li (लेखक), Mary Duke (लेखक), Malcolm K Jones (लेखक), Ling Kuang (लेखक), Jianfeng Zhang (लेखक), David Blair (लेखक), Yuesheng Li (लेखक), Donald P McManus (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: Public Library of Science (PLoS), 2011-01-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

BACKGROUND: Schistosoma mansoni tetraspanin 2 (Sm-TSP-2) has been shown to be strongly recognized by IgG1 and IgG3 antibodies from individuals putatively resistant to schistosome infection, but not chronically infected people, and to induce high levels of protection against challenge infection in th...