Inconsistent protective efficacy and marked polymorphism limits the value of Schistosoma japonicum tetraspanin-2 as a vaccine target.

• Main Authors: Wenbao Zhang (Author), Jun Li (Author), Mary Duke (Author), Malcolm K Jones (Author), Ling Kuang (Author), Jianfeng Zhang (Author), David Blair (Author), Yuesheng Li (Author), Donald P McManus (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2011-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

BACKGROUND: Schistosoma mansoni tetraspanin 2 (Sm-TSP-2) has been shown to be strongly recognized by IgG1 and IgG3 antibodies from individuals putatively resistant to schistosome infection, but not chronically infected people, and to induce high levels of protection against challenge infection in th...