Predicting Volume of Distribution in Neonates: Performance of Physiologically Based Pharmacokinetic Modelling

• Những tác giả chính: Pieter-Jan De Sutter (Tác giả), Phebe Rossignol (Tác giả), Lien Breëns (Tác giả), Elke Gasthuys (Tác giả), An Vermeulen (Tác giả)
• Định dạng: Sách
• Được phát hành: MDPI AG, 2023-09-01T00:00:00Z.
• Những chủ đề: article
• Truy cập trực tuyến: Connect to this object online.

The volume of distribution at steady state (Vss) in neonates is still often estimated through isometric scaling from adult values, disregarding developmental changes beyond body weight. This study aimed to compare the accuracy of two physiologically based pharmacokinetic (PBPK) Vss prediction method...