Loss of mitochondrial pyruvate carrier 1 supports proline-dependent proliferation and collagen biosynthesis in ovarian cancer

• المؤلفون الرئيسيون: M. Rufaik Farook (مؤلف), Zack Croxford (مؤلف), Steffan Morgan (مؤلف), Anthony D. Horlock (مؤلف), Amy K. Holt (مؤلف), April Rees (مؤلف), Benjamin J. Jenkins (مؤلف), Carmen Tse (مؤلف), Emma Stanton (مؤلف), D. Mark Davies (مؤلف), Catherine A. Thornton (مؤلف), Nicholas Jones (مؤلف), I. Martin Sheldon (مؤلف), Emma E. Vincent (مؤلف), James G. Cronin (مؤلف)
• التنسيق: كتاب
• منشور في: Elsevier, 2024-03-01T00:00:00Z.
• الموضوعات: article
• الوصول للمادة أونلاين: Connect to this object online.

The pyruvate transporter MPC1 (mitochondrial pyruvate carrier 1) acts as a tumour-suppressor, loss of which correlates with a pro-tumorigenic phenotype and poor survival in several tumour types. In high-grade serous ovarian cancers (HGSOC), patients display copy number loss of MPC1 in around 78% of...