Loss of mitochondrial pyruvate carrier 1 supports proline-dependent proliferation and collagen biosynthesis in ovarian cancer

• Main Authors: M. Rufaik Farook (Author), Zack Croxford (Author), Steffan Morgan (Author), Anthony D. Horlock (Author), Amy K. Holt (Author), April Rees (Author), Benjamin J. Jenkins (Author), Carmen Tse (Author), Emma Stanton (Author), D. Mark Davies (Author), Catherine A. Thornton (Author), Nicholas Jones (Author), I. Martin Sheldon (Author), Emma E. Vincent (Author), James G. Cronin (Author)
• פורמט: ספר
• יצא לאור: Elsevier, 2024-03-01T00:00:00Z.
• נושאים: article
• גישה מקוונת: Connect to this object online.

The pyruvate transporter MPC1 (mitochondrial pyruvate carrier 1) acts as a tumour-suppressor, loss of which correlates with a pro-tumorigenic phenotype and poor survival in several tumour types. In high-grade serous ovarian cancers (HGSOC), patients display copy number loss of MPC1 in around 78% of...