An extremely rare case of concurrent BRAF V600E mutation driven hairy cell leukemia and melanoma: case report and review of literature

• Asıl Yazarlar: Amir Ghorbani-Aghbolaghia (Yazar), Mirna Lechpammer (Yazar), Saba F. Ali (Yazar), Nam K. Ku (Yazar), Denis M. Dwyre (Yazar), Hooman H. Rashidi (Yazar)
• Materyal Türü: Kitap
• Baskı/Yayın Bilgisi: University of São Paulo, 2017-09-01T00:00:00Z.
• Konular: article
• Online Erişim: Connect to this object online.

BRAF protein is a serine/threonine kinase with 766 amino acids. Approximately 15% of human cancers harbor BRAF mutations as well as other BRAF anomalies (amplifications, fusions). Somatic mutations mainly occur in the catalytic kinase domain (CR3), and the predominant mutation is p.V600E which is th...