A novel strategy for treatment of cancer cachexia targeting xanthine oxidase in the brain

• Main Authors: Miaki Uzu (Author), Miki Nonaka (Author), Kanako Miyano (Author), Hiromi Sato (Author), Nagomi Kurebayashi (Author), Kazuyoshi Yanagihara (Author), Takashi Sakurai (Author), Akihiro Hisaka (Author), Yasuhito Uezono (Author)
• Format: Book
• Published: Elsevier, 2019-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Cancer cachexia is a systemic wasting syndrome characterized by anorexia and loss of body weight. The xanthine oxidase (XO) inhibitor febuxostat is one of the promising candidates for cancer cachexia treatment. However, cachexic symptoms were not alleviated by oral administration of febuxostat in ou...