Developing In Situ Chemometric Models with Raman Spectroscopy for Monitoring an API Disproportionation with a Complex Polymorphic Landscape

• Main Authors: Shikhar Mohan (Author), Yi Li (Author), Kevin Chu (Author), Bing Shi (Author), Liliana De La Paz (Author), Prarthana Bakre (Author), Chris Foti (Author), Victor Rucker (Author), Chiajen Lai (Author)
• Format: Book
• Published: MDPI AG, 2023-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

An in situ Raman method was developed to characterize the disproportionation of two salts involving a complex polymorphic landscape comprising up to two metastable and one stable freebase forms. Few precedents exist for Raman calibration procedures for solid form quantitation involving more than two...